45 Pfeiffer Rd German-Inspired Hill Country Estate with large guesthouse/ multi use space - Unrestricted and Just Off the 290 Wine Trail. Luxury, flexibility, and timeless design come together on this stunning 6.85 acre Fredericksburg estate-ideal for private living, short-term rental, or commercial use such as a tasting room or event space. Located along the sought-after 290 Wine Trail, this gated 2-story property offers an exceptional lifestyle and income opportunity with no restrictions. The main residence showcases a light-filled, open layout with vaulted wood-beam ceilings, travertine floors, and a floor-to-ceiling limestone fireplace. The chef's kitchen features custom cabinetry, glass-front uppers, a farmhouse sink, and premium Wolf appliances, all centered around a stylish butcher block island. The main house also has an attached double garage. The spacious dining and living areas offer panoramic views and effortless flow-perfect for entertaining or relaxing. A grand entry with bead board ceilings leads to the main-level primary suite, which includes a generous layout and a spa-inspired bath with soaking tub, walk-in shower, and dual vanities. Upstairs, enjoy a versatile game/media room and private office space with 3 bedrooms and 2 bathrooms. The detached guest house features 3 bedrooms, 3.5 bathrooms, a full kitchen, and an expansive living area. Downstairs, a massive workshop/game area and oversized garage add serious functionality-whether for hobbies, events, or business use. Outdoors, unwind under the covered pergola with stone fireplace, soak in the private hot tub, or take in scenic views from the second-story balcony. Whether you're looking for a multi-generational retreat, an STR investment, or a commercial vision in a top-tier location, this property delivers.