422 Main St Discover a rare downtown La Crosse opportunity at 422-424 Main St. Formerly ''The Main'' event venue, this property blends historic character with modern versatility--featuring a large stage, lighting, bar, kitchen equipment, and a corner office suite. The expansive lower level offers ideal storage or additional build-out potential. The upper level at 424 Main is a luxury apartment currently used as a short-term rental, providing proven income. Keep the event use or reimagine the space for your vision--steps from restaurants, nightlife, and the riverfront. A flexible commercial property in the heart of downtown energy. All equipment is negotiable for a seamless transition. We'll help you shape the vision.