1544 Mississippi River Boulevard S Set on nearly half an acre along iconic Mississippi River Boulevard, this rare one-story walkout home offers an exceptional combination of space, privacy, and convenience in the heart of St. Paul’s coveted Highland neighborhood. Positioned near a bend in the Mississippi River, the property is one of just a handful of one-story homes on River Road where the river, its surrounding landscape and foliage, and the downtown Minneapolis skyline can be enjoyed from inside the home. The main level features a spacious living room with beautiful hardwood floors and a wood-burning fireplace, ideal for both everyday living and entertaining. The private and sizable main level owner’s suite is tucked in the back of the home, overlooking the expansive backyard, and includes a large walk-in closet and its own bathroom. The kitchen, complete with a large center island, and the informal dining area overlook and walk out to the deck and massive, private backyard—an exceptionally large and secluded lot by St. Paul standards. A versatile flex room, adjacent to the kitchen and dining area, offers space for a TV, reading nook, home office, or homework area. An additional bedroom, full bathroom, and formal dining area complete the main level. Two separate staircases lead to the lower level, which includes a generously-sized family room, recreation room, two additional bedrooms, and a bathroom with walk-in shower, along with ample storage and workshop space. Recent updates include a new roof in 2022, new carpet in 2025, and a Sub-Zero refrigerator in 2021. Located across the street from the river and its renowned trail system, and within walking distance of the Highland Bridge Development, neighborhood shops and dining, and Hidden Falls Regional Park, this home also offers quick access to the airport. Lovingly cared for by its owners for the past 29 years, the home has been well maintained yet presents an excellent opportunity for the next owner to bring their own vision, updates, and finishing touches to make it their own over time.