14748 Valerio Street There's no place like home for the Holidays! If you're seeking a house with a GUEST HOUSE this could be the one for you. Step into this enchanting 1930s SPANISH-STYLE COMPOUND, a timeless retreat that captures the essence of classic California living in the heart of Van Nuys. Blending original character with modern comfort, this GATED estate rests on an expansive 13, 518 SQUARE FOOT LOT and offers over 2, 652 square feet in the MAIN HOUSE, plus a detached GUEST HOUSE of approximately 472 square feet, perfect for multi-generational living or creative space. Inside, arched passageways, custom etched-glass windows, and built-ins highlight the home’s authentic charm. The inviting layout features a spacious living room with fireplace, an elegant dining room, family room, and a versatile bonus room ideal for an office or additional bedroom. The kitchen includes painted cabinets, tile countertops, and newer STAINLESS STEEL APPLINCES, with a large picturesque breakfast nook window overlooking the backyard. The primary suite offers a walk-in shower, DUAL VANITIES, WALK-IN-CLOSET, and soaking tub. The UPSTAIRS STUDIO or music room showcases CATHEDRAL-STYLE EXPOSED WOOD-BEAM ceilings, a WET BAR, refrigerator, and two balconies overlooking both the front and back yards. Outdoors, enjoy a resort-like atmosphere with a SPARKLING POOL, OUTDOOR BBQ KITCHEN, and mature fig, avocado, and lemon trees. RV access, a carport, two-car garage, and a RARE HORSESHOE DRIVEWAY provides ample secured parking. The home has been fully RE-WIRED and upgraded with NEW A/C, COPPER PLUMBING, and modernized electrical systems. The DETACHED GUEST HOUSE includes its own bedroom, kitchen, and bathroom with tall ceilings. With its generous lot and flexible layout, the property offers excellent potential for SB9, ADU, or JADU development. Its flexible configuration and generous square footage could be well-suited for use as a drug and alcohol rehab facility, offering an excellent opportunity for healthcare or recovery-focused operators. Conveniently located near Sherman Oaks, Burbank, Encino, and Studio City, and just 10 minutes from the Sherman Oaks Whole Foods and Ventura Blvd, this peaceful haven embodies the very best of San Fernando Valley living.