106 S Main Street Prime Downtown Commercial Lease Opportunity! Now available is this approximately 1, 200 sq ft mixed-use commercial space located in the heart of historic downtown Poplar Bluff. The interior is currently configured with 2–3 private office spaces, a common work or reception area, and one restroom, offering flexibility for a variety of professional, retail, or service-based uses. This property features a street-level storefront with excellent overhead signage potential, providing strong visibility and branding opportunities in a high-traffic, central location. On-street parking is readily available, along with a private parking lot for additional convenience. Previously occupied by a government agency, the space offers a solid, functional layout and is now ready for a new tenant to customize and make their own. With its central location, flexible floor plan, and strong visibility, this space is well-suited for office, retail, studio, or professional services. Schedule your showing today and position your business in one of downtown Poplar Bluff’s most traveled locations.